hypermethylation相关论文
Aberrant p16 promoter hypermethylation in bronchial mucosae as a biomarker for the early detection o
Lung cancer is the leading cause of cancer related death in the world and its mortality could be greatly reduced by dia......
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抑癌基因启动子过甲基化是除基因突变和染色体物质缺失外抑癌基因失活的第3种机制,某些情况下是抑癌基因失活的惟一机制.目前抑癌......
背景GATA转录因子家族在胚胎发育时期能够促进胃肠道的正常发育,并有助于在成年肠上皮的不断更新中调节组织分化,最近有报道在人胃......
The relationship between hypermethylation of CpG islands in the promoter regions of O6methylguanine DNA methyltransferas......
目的 探讨胱硫醚-β-合酶(CBS)启动子区的超甲基化与基因表达及功能的相关性.方法 通过结合重亚硫酸盐处理的直接测序、实时定量聚......
AIM: To determine pl6 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on pl6-protein e......
Hypermethylation and aberrant expression of secreted fizzled-related protein genes in pancreatic can
AIM:To determine the methylation status and aberrant expression of some secreted frizzled-related protein (SFRP) genes i......
Pancreatic cancer is one of the malignant tumor with a very poor prognosis. Both genetic and epigenetic alterations are ......
Aberrant p16 promoter hypermethylation in bronchial mucosae as a biomarker for the early detection o
Lung cancer is the leading cause of cancer related death in the world and its mortality could be greatly reduced by diag......
DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用。文中主要综述了几十年来人们对DNA甲基化异常与基因转录及......
目的探讨原发性结肠腺癌组织与相应癌旁组织中E-cadherin（E-cad）基因异常甲基化改变及其蛋白表达的特点。以及其与结肠腺癌发生发展......
染色质解旋酶DNA结合蛋白5（CHD5）属于染色质重塑酶,其既能重塑染色质促进基因转录,又能正向调控p53/p19arf控制细胞增殖、凋亡和衰老......
目的检测不同类型脑肿瘤患者肿瘤组织和血浆DNA中P16基因启动子区CpG岛甲基化状态，探讨P16基因甲基化与脑肿瘤发生发展的关系以及血......
P15基因是肿瘤抑制基因的侯选基因,受细胞生长抑制蛋白TGF-β的诱导,编码周期素依赖激酶4/6(CDK4/6)抑制因子,对细胞周期起负调控......
目的：研究 p16基因在脑胶质瘤中的纯合性缺失、高甲基化和突变等结构变化及其与表达之间的关系。方法：应用聚合酶链反应（ polymerase ......
DNA甲基化是哺乳动物基因组最常见的修饰方式,它存在于生物体正常的生理过程,DNA异常甲基化和疾病的发生发展有关.该文综述了癌症......
